Leptospirosis Shots For Dogs. Killed vaccines can be effective, but typically require multiple doses given within a specific interval to maximize immunity. A key objective of vaccination is to prevent urinary shedding of leptospires, which has potential zoonotic risk:
The leptospirosis vaccine is the most likely of all dog vaccinations to cause an adverse reaction in the dog. Icterohaemorrhagiae, and 50% of control dogs challenged with. The leptospirosis vaccine gives a short duration of immunity (less than 1 year).